Why would already abundant ‘natural killer’ cells proliferate even further after subduing an infection? It’s been a biological mystery for 30 years. But now Brown University scientists have an answer: After proliferation, the cells switch from marshaling the immune response to calming it down. The findings illuminate the functions of a critical immune system cell important for early defense against disease induced by viral infection.
In Science Translational Medicine scientists reveal the key role that an ancient protein plays in the course of idiopathic pulmonary fibrosis. The research offers more than an unprecedentedly detailed explanation of the disease’s tragic course. It also points toward a new therapeutic strategy.